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Bioorg Med Chem Lett. 2014 Jan 15;24(2):508-9. doi: 10.1016/j.bmcl.2013.12.032. Epub 2013 Dec 16.

Truncated norzoanthamine exhibiting similar collagen protection activity, toward a promising anti-osteoporotic drug.

Author information

  • 1Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • 2Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: seketsuf@chem.s.u-tokyo.ac.jp.

Abstract

The marine alkaloid, norzoanthamine, is considered to be a promising drug for osteoporosis treatment. Due to its rarity and complicated structure, a practical supply method must be developed. Here, we designed a truncated norzoanthamine, which has two-thirds of the original structure, and found that it exhibited similar collagen protection activity.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Alkaloid; Collagen; Norzoanthamine; Osteoporosis

PMID:
24374275
[PubMed - indexed for MEDLINE]
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