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Neurosci Lett. 2014 Feb 21;561:41-5. doi: 10.1016/j.neulet.2013.12.036. Epub 2013 Dec 25.

Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau.

Author information

  • 1Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159 Mannheim, Germany. Electronic address: michael.deuschle@zi-mannheim.de.
  • 2Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159 Mannheim, Germany.
  • 3Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 München, Germany; Center of Mental Health Klinikum Ingolstadt, Krumenauerstraße 25, 85049 Ingolstadt, Germany.
  • 4LVR-Hospital Essen, Deparment of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Virchowstrasse 174, 45147 Essen, Germany.
  • 5LVR-Hospital Essen, Deparment of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Virchowstrasse 174, 45147 Essen, Germany; Dept. of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany.
  • 6Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159 Mannheim, Germany; Department of Psychiatry, Charite, Eschenalle 3, 14050 Berlin, Germany.

Abstract

It has been suggested that sleep-wake regulation as well as hypocretins play a role in the pathophysiology of Alzheimer's disease. We analyzed Aβ40, Aβ42, Tau protein, phosphorylated Tau (pTau) protein as well as hypocretin-1 concentrations in the CSF of a detection sample of 10 patients with Alzheimer's disease (AD) as well as 10 age- and gender-matched patients with major depression as a comparison group of different pathology. In order to replicate the findings, we used a confirmation sample of 17 AD patients and 8 patients with major depression. We found hypocretin-1 concentrations in CSF not to differ between patients with depression and AD. However, hypocretin-1 was significantly related to Tau (r=0.463, p<0.001) and pTau (r=0.630, p<0.0001). These effects were more pronounced in depressed patients when compared to AD patients. We conclude that hypocretin-1 may play a role in the metabolism of Tau proteins across different diagnostic entities including AD. It has to be determined whether there is a causal relationship between hypocretin-1 and Tau as well as pTau.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Alzheimer's disease; Aβ; Depression; Hypocretin; Orexin; Tau protein

PMID:
24373987
[PubMed - in process]
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