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Neurosci Lett. 2014 Feb 7;560:137-41. doi: 10.1016/j.neulet.2013.12.034. Epub 2013 Dec 22.

Effect of fat free mass on serum and plasma BDNF concentrations during exercise and recovery in healthy young men.

Author information

  • 1Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, United Kingdom.
  • 2Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom. Electronic address: rramsbottom@brookes.ac.uk.
  • 3Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
  • 4School of Sport, Performing Arts and Leisure, University of Wolverhampton, WS1 3BD, United Kingdom.

Abstract

Exercise results in release of brain derived neurotrophic factor into the circulation; however, little is known about the changes in serum and plasma brain derived neurotrophic factor concentrations and factors influencing brain derived neurotrophic factor during exercise and recovery. Serum (n=23) and plasma (n=10) brain derived neurotrophic factor concentrations were measured in healthy young men at rest, during steady-rate and after exercise to determine the maximum aerobic power. A two-way analysis of variance was used to investigate brain derived neurotrophic factor levels in blood during exercise and recovery, with one between-subject factor (a median split on: age, height, body mass, fat free mass, body mass index and aerobic fitness), and one within-subject factor (time). Serum brain derived neurotrophic factor concentrations increased in response to exercise and declined rapidly in recovery. Plasma brain derived neurotrophic factor had a greater proportional increase relative to exhaustive exercise compared with serum brain derived neurotrophic factor and was slower to return to near baseline values. There was a significant group-by-time interaction indicating a greater release and faster recovery for serum brain derived neurotrophic factor in high- compared with low-fat free mass individuals.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

BDNF; Exercise; Plasma; Serum

PMID:
24368215
[PubMed - indexed for MEDLINE]
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