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Nat Rev Urol. 2014 Feb;11(2):77-9. doi: 10.1038/nrurol.2013.307. Epub 2013 Dec 24.

From molecular understanding to clinical advances.

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  • 1Genito-urinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.


Big data and computational biology brought to the forefront a number of potential actionable mutations and drug targets in clear cell renal cell carcinoma in 2013. As we continue to unravel the molecular underpinnings of tumorigenesis and progression, the clinical benefits will eventually be reaped.

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