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Molecules. 2013 Dec 23;19(1):149-58. doi: 10.3390/molecules19010149.

Molecular docking characterization of a four-domain segment of human fibronectin encompassing the RGD loop with hydroxyapatite.

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  • 1School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. jweng@swjtu.edu.cn.


Fibronectin adsorption on biomaterial surfaces plays a key role in the biocompatibility of biomedical implants. In the current study, the adsorption behavior of the 7-10th type III modules of fibronectin (FN-III7-10) in the presence of hydroxyapatite (HAP) was systematically investigated by using molecular docking approach. It was revealed that the FN-III10 is the most important module among FN-III7-10 in promoting fibronectin binding to HAP by optimizing the interaction energy; the arginine residues were observed to directly interact with the hydroxyl group of HAP through electrostatic forces and hydrogen bonding. Moreover, it was found that the HAP-binding sites on FN-III10 are mainly located at the RGD loop region, which does not affect the interaction between the fibronectin protein and its cognate receptors on the cell surface.

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