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Handb Clin Neurol. 2014;121:1561-94. doi: 10.1016/B978-0-7020-4088-7.00104-8.


Author information

  • 1Department of Neurology, CHU La Milétrie, Poitiers, France. Electronic address: jph.neau@chu-poitiers.fr.
  • 2Department of Neurology, CHU La Milétrie, Poitiers, France.
  • 3Department of Dermatology, CHU La Milétrie, Poitiers, France.


Since the skin and the central and/or peripheral nervous system share a common source (the ectoderm), numerous genetic and acquired diseases (infectious, tumoral or autoimmune disorders) equally affect both. Neurologic diseases or symptoms such as stroke, cerebral or medullary vascular malformations, peripheral, brain or medullary tumors, epilepsy, ataxia, neurologic infections, or cognitive disorders (dementia, mental retardation) may be associated with specific cutaneous manifestations of which the discovery can facilitate the final diagnosis, thereby leading to specific treatment and/or genetic investigations. Careful examination of the skin, hair, and nails by the neurologist is consequently of the utmost importance; when unusual abnormalities of the skin are discovered or when greater expertise is required, consultation with a dermatologist is frequently advisable.

© 2014 Elsevier B.V. All rights reserved.


Dermatological symptoms; brain and peripheral tumors; cognitive deficit; cutaneous angioma; epilepsy; genetic disorders; peripheral neuropathy; stroke

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