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Nutr Metab Cardiovasc Dis. 2014 May;24(5):524-31. doi: 10.1016/j.numecd.2013.10.032. Epub 2013 Dec 1.

Microvascular disorders in obese Zucker rats are restored by a rice bran diet.

Author information

  • 1Department of Pharmacology, School of Pharmacy, University of Seville, Seville, Spain.
  • 2Departament de Farmacologia, Terapèutica i Toxicologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • 3Department of Pharmacology, School of Pharmacy, University of Seville, Seville, Spain. Electronic address: rodriguezr@us.es.



Nutritional-based approaches aimed to prevent microvascular dysfunction associated to obesity present potential advantages over pharmacological strategies. Our aim was to test whether a rice bran enzymatic extract (RBEE)-supplemented diet could attenuate microvascular alterations in obese rats.


Lean and obese Zucker rats were fed standard diet supplemented or not with 1% and 5% RBEE for 20 weeks. Functional studies were performed in small mesenteric arteries in isometric myograph. Immunoblotting and fluorescence studies were made in arterial homogenates and arterial sections, respectively. RBEE-supplementation restored microvascular function in obese rats through a marked increase in NO and endothelial-derived hyperpolarizing factor contribution by up-regulation of eNOS and calcium-activated potassium channels expression, respectively, in association to a substantial reduction of microvascular inflammation and superoxide anion formation. These data agrees with the beneficial actions of RBEE on dyslipidemia, hyperinsulinemia and hypertension in obesity.


The multi-factorial properties of RBEE-diet, especially for restoring the function of small resistance arteries shows this dietary-based approach to be a promising candidate for prevention of microvascular alterations in obesity, which are crucial in cardiovascular events in obese subjects.

Copyright © 2013 Elsevier B.V. All rights reserved.


Mesenteric artery; Microvascular function; Obese Zucker rat; Obesity; Rice bran

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