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N Am J Med Sci. 2013 Oct;5(10):611-4. doi: 10.4103/1947-2714.120799.

Correlation of severity of coronary artery disease with insulin resistance.

Author information

  • 1Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
  • 2Department of Cardiology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
  • 3Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
  • 4Department of Community Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
  • 5Jr. Resident, Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.

Abstract

BACKGROUND:

Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail.

AIMS:

The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus.

MATERIALS AND METHODS:

In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score.

RESULTS:

There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant.

CONCLUSIONS:

The results of our study indicate that we might able to predict the severity of CAD by measure of IR.

KEYWORDS:

Coronary artery disease; Insulin resistance; Type 2 diabetes mellitus

PMID:
24350075
[PubMed]
PMCID:
PMC3842704
Free PMC Article

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