Phenytoin-induced cerebellar atrophy in an epileptic boy

Indian J Pharmacol. 2013 Nov-Dec;45(6):636-7. doi: 10.4103/0253-7613.121388.

Abstract

Epilepsy is an important health problem due to its high prevalence and potential for causing long-term morbidity. It is commonly treated in children with phenytoin sodium. It has wide pharmacokinetic variability and a narrow therapeutic range that leads to toxicity. Here, we report a case of phenytoin-induced cerebellar atrophy in a 16-year-old epileptic boy who presented to the hospital with a viral infection.

Keywords: Adverse drug reaction; antiepileptic drugs; antiseizure drugs; cerebellar atrophy; phenytoin.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anticonvulsants / adverse effects*
  • Cerebellum / pathology*
  • Epilepsy / complications*
  • Humans
  • Male
  • Phenytoin / adverse effects*

Substances

  • Anticonvulsants
  • Phenytoin