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J Cardiovasc Pharmacol Ther. 2014 May;19(3):244-55. doi: 10.1177/1074248413511691. Epub 2013 Dec 16.

A systematic review and meta-analysis of the effects of pycnogenol on plasma lipids.

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  • 1Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

BACKGROUND:

Pycnogenol, the standardized flavonoid-rich extract from the bark of French maritime pine (Pinus pinaster Ait), has been shown to modify a number of cardiovascular risk factors. However, that Pycnogenol modulates plasma lipid levels is unclear due to the inconsistent findings.

OBJECTIVE:

To examine the impact of Pycnogenol on lipid profile through a meta-analysis of available controlled clinical trials.

METHODS:

Controlled trials assessing the effects of Pycnogenol on lipid parameters (total cholesterol, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglycerides) were identified by electronic search in Medline and Scopus. Weighed mean difference (WMD) and 95% confidence interval (CI) were calculated as effect size using random-effects meta-analysis. Sensitivity and meta-regression (for Pycnogenol dose and duration of supplementation) analyses were carried out using leave-one-out and unrestricted maximum likelihood methods, respectively.

RESULTS:

A total of 7 trials comprising 442 patients (226 in the Pycnogenol and 216 in the control group) were identified. Meta-analysis did not reveal any significant effect of Pycnogenol on lipid parameters: total cholesterol: WMD: -0.03 mmol/L, 95% CI: -0.34 to 0.28, P = .83; LDL-C: WMD: -0.07 mmol/L, 95% CI: -0.29 to 0.15, P = .54; HDL-C: WMD: 0.00 mmol/L, 95% CI: -0.04 to 0.05, P = .86; and triglycerides: WMD: 0.05 mmol/L, 95% CI: -0.12 to 0.23, P = .55. All these effect sizes were robust in sensitivity analyses. Apart from a dose-effect association for the effect of Pycnogenol on LDL-C, there was no other association between Pycnogenol dose or its duration of supplementation with changes in any of the lipid parameters.

CONCLUSION:

Current clinical evidence does not suggest any significant effect of Pycnogenol on fasting lipid profile.

KEYWORDS:

Pinus pinaster; cardiovascular disease; dyslipidemia; flavonoid; quantitative data synthesis; randomized controlled trial

PMID:
24346156
[PubMed - in process]
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