Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Cell Biol. 2014 Jan-Feb;93(1-2):82-6. doi: 10.1016/j.ejcb.2013.10.010. Epub 2013 Nov 4.

Human relevance of NRAS/BRAF mouse melanoma models.

Author information

  • 1Institut Curie, Normal and Pathological Development of Melanocytes, 91405 Orsay, France; CNRS UMR3347, France; INSERM U1021, France.
  • 2Institut Curie, Normal and Pathological Development of Melanocytes, 91405 Orsay, France; CNRS UMR3347, France; INSERM U1021, France. Electronic address: lionel.larue@curie.fr.

Abstract

Melanoma is a major problem for many individuals worldwide. Although no effective treatment is available, promising new strategies are being developed. A better understanding of the inner workings of the disease would undoubtedly lead to improved treatments. Mouse melanoma models have been used to elucidate many key regulatory pathways involved in melanoma initiation and progression, and models with mutations in the oncogenes RAF and RAS have been particularly informative. Here, we summarize and evaluate the human relevance of various RAF and RAS mouse melanoma models and their contribution to our understanding of melanoma.

Copyright © 2013 Elsevier GmbH. All rights reserved.

KEYWORDS:

Initiation; Melanomagenesis; PTEN; Progression; p16(INK4A); β-Catenin

PMID:
24342721
[PubMed - in process]

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk