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Chin Med J (Engl). 2013;126(24):4660-4.

Upregulation of glucosylceramide synthase protein in papillary thyroid carcinoma.

Author information

  • 1Department of Nuclear Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
  • 2Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, China.
  • 3Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
  • 4Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China. Email: wangqiangxiu@163.com.
  • 5Department of Ultrasonography, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.

Abstract

BACKGROUND:

Glucosylceramide synthase (GCS) can reduce ceramide levels and help cells escape ceramide-induced apoptosis, thus leading to multidrug resistance (MDR). However, its expression and clinical significance in thyroid neoplasms still remain unclear. We aimed to elucidate the expression of GCS and explore its correlation with the clinicopathological characteristics in papillary thyroid carcinomas (PTCs).

METHODS:

We retrospectively investigated GCS protein expression level in tissue specimens obtained from 108 consecutive PTC patients by immunohistochemistry and Western blotting.

RESULTS:

GCS was weakly positive or negative in normal follicular cells, but it was frequently overexpressed in PTC cells. GCS overexpression was associated with primary tumor size, local infiltration, lymph node metastasis, and local recurrence, but not associated with gender, age, pathological variants, tumor multifocality, tumor stage or distant metastasis. Western blotting also showed that GCS protein levels were much higher in PTCs' tissues than in normal thyroid tissues.

CONCLUSION:

GCS was upregulated in PTCs and might be an independent factor affecting prognosis.

PMID:
24342307
[PubMed - indexed for MEDLINE]
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