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World J Clin Cases. 2013 Oct 16;1(7):220-3. doi: 10.12998/wjcc.v1.i7.220.

Cytomegalovirus enteritis with jejunal perforation in a patient with endometrial adenocarcinoma.

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  • 1Young Jin Jun, Jongmin Sim, Hye In Ahn, Hulin Han, Hyunsung Kim, Kijong Yi, Abdul Rehman, Se Min Jang, Kiseok Jang, Seung Sam Paik, Department of Pathology, College of Medicine, Hanyang University, Seoul 133-792, South Korea.


Cytomegalovirus (CMV) infection of the gastrointestinal tract has been reported most frequently in the setting of immunodeficiency. The whole gastrointestinal tract can be affected; however, the small bowel is rarely affected. We report a case of CMV enteritis with jejunal perforation in a 53-year-old woman with a history of chemoradiation therapy for endometrial cancer 8 years previously. At follow-up evaluation, lower abdominal pain, diarrhea and vomiting appeared. Abdominal computed tomography showed intra-abdominal free air in the subphrenic space and porta hepatis. The jejunal segment revealed serosal purulent exudates with a perforation. The resected jejunal segment showed a large geographic ulcerative mucosal lesion. The microscopic findings revealed a diffuse ulcerative mucosal change with a prominent granulation tissue formation and many large atypical vascular endothelial cells and stromal fibroblasts with intranuclear or intracytoplasmic inclusion bodies. These cells were positive for CMV antibody. The final diagnosis was CMV-associated jejunitis with a jejunal perforation.


Cytomegalovirus; Enteritis; Jejunum; Perforation

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