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Nanotechnology. 2014 Jan 17;25(2):025101. doi: 10.1088/0957-4484/25/2/025101. Epub 2013 Dec 12.

Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe2O4 and Fe3O4 metal cores.

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  • 1Department of Biomedical Engineering, Technological Educational Institute of Athens, Agiou┬áSpiridonos 28, 12210, Egaleo, Greece. Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety, N.C.S.R. 'Demokritos', 15310, Agia Paraskevi, Greece.


Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core-shell nanosystems, bearing either magnetite (Fe3O4) or cobalt ferrite (CoFe2O4) cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition.

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