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Cancer Discov. 2013 Dec;3(12):1330-2. doi: 10.1158/2159-8290.CD-13-0775.

Dynamic interplay of oncogenes and T cells induces PD-L1 in the tumor microenvironment.

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  • 11Abramson Family Cancer Research Institute; 2Abramson Cancer Center; 3Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.


Tumor-infiltrating T cells have recently been found to upregulate immunosuppressive pathways, such as programmed cell death protein 1 ligand 1 (PD-L1), in a paracrine fashion on tumor cells, but tumor cell-intrinsic regulation of PD-L1 is another potential mechanism. In this issue of Cancer Discovery, Akbay and colleagues show that signaling via mutant EGF receptor (EGFR) in murine lung tumor cells directly upregulates tumor PD-L1 and that therapeutic blockade of this pathway improves survival in EGFR-driven preclinical models-highlighting the dynamic interplay and therapeutic opportunities of cancer cell biology and immune biology.

©2013 AACR.

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