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J Labelled Comp Radiopharm. 2014 Mar;57(3):121-4. doi: 10.1002/jlcr.3156. Epub 2013 Dec 11.

Development of an automated system for preparation of liquid scintillation counting samples for radiolabeled pharmaceuticals.

Author information

  • 1Merck Research Laboratories, Merck and Co., Inc., Rahway, NJ, 07065, USA.

Abstract

Radiolabeled compounds are essential tools in drug development used to obtain critical metabolism and safety information. To support the synthesis and ensure quality of radiolabeled compounds for all programs, bench automation has been implemented in our laboratories. The concept of a platform technology for bench-top automation is not new. A considerable investment in the automation of various critical analytical laboratory workflows to both harmonize the efforts of a large and diverse global organization and minimize capital footprint has been made on our part. Various custom automation techniques and applications have been developed to increase capabilities and productivity of radiochemical analyses at Merck. In this paper, we will present a novel system that is capable of automating the liquid scintillation counting procedure. The system has handled multiple radiolabeled ((3)H, (14)C, and (35)S) pharmaceutical compounds with an accuracy of 5% with a standard deviation of 2% and a cycle time of ~10 min per analysis.

Copyright © 2013 John Wiley & Sons, Ltd.

KEYWORDS:

14C; 35S; analytical; liquid scintillation counting

PMID:
24327404
[PubMed - in process]
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