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Chemistry. 2014 Jan 3;20(1):58-63. doi: 10.1002/chem.201303802. Epub 2013 Dec 10.

A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide.

Author information

  • 1Key Laboratory of Applied Surface and Colloid, Chemistry of Ministry of Education, Department of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062 (China).


DMSO methylates a broad range of amines in the presence of formic acid, providing a novel, green and practical method for amine methylation. The protocol also allows the one-pot transformation of aromatic nitro compounds into dimethylated amines in the presence of a simple iron catalyst.

Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


DMSO; amines; deuterium labelling; formic acid; methylation

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