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J Vasc Interv Radiol. 2014 Apr;25(4):511-20. doi: 10.1016/j.jvir.2013.09.018. Epub 2013 Dec 8.

Roll-in experience from the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) study.

Author information

  • 1Vascular Disease Research Center, Rhode Island Hospital, Gerry 337, 593 Eddy Street, Providence, RI 02903. Electronic address:
  • 2Division of Cardiology, University of Toledo, Toledo, Ohio.
  • 3Division of Cardiology, Beth Israel Deaconess Hospital, Boston; Harvard Clinical Research Institute, Boston.
  • 4Department of Radiology, University of Virginia, Charlottesville, Virginia.
  • 5Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan.
  • 6Interventional Institute, Holy Name Medical Center, Teaneck, New Jersey.
  • 7Division of Cardiology, Massachusetts General Hospital, Boston.
  • 8University of Texas Health Sciences at San Antonio, San Antonio, Texas.
  • 9Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
  • 10Harvard Clinical Research Institute, Boston; Department of Biostatistics, Boston University, Boston, Massachusetts.
  • 11Harvard Clinical Research Institute, Boston.
  • 12National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
  • 13Division of Nephrology, Rhode Island Hospital, Gerry 337, 593 Eddy Street, Providence, RI 02903.



To describe the experience and results from the roll-in phase of the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) study.


The CORAL roll-in database was used to describe the baseline characteristics of the patients in the roll-in cohort, all of whom underwent renal artery stent placement; to evaluate CORAL site performance; to compare estimates of lesion (stenosis) severity made by site interventionalists with the central CORAL angiographic core laboratory readings; and to report outcomes after renal artery stent placement. During the roll-in phase, 239 patients (mean age, 70.2 y ± 9.0; 49% male) underwent renal artery stent procedures. Angiographic core laboratory analysis of renal arteriograms was done, and participants were followed at 1 month and 9 months.


Major angiographic complications were identified in 28 (13%) subjects. Kidney function remained unchanged at the short (2-4 weeks) follow-up interval. Improvement in systolic blood pressure with use of distal embolic protection devices (n = 161) did not show any clinical benefit over nonuse of such devices (n = 78) in this small series. At 9 months, there were significantly more endpoints reported by site in subjects with bilateral renal artery stenosis (P = .01) and prior history of stroke (P = .03).


In the roll-in phase of the CORAL study, a significant number of angiographic complications were identified. No effect was seen on estimated glomerular filtration rate after renal artery stent placement, but systolic blood pressure decreased significantly.

© 2013 Published by SIR on behalf of The Society of Interventional Radiology.

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