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Molecules. 2013 Dec 6;18(12):15126-33. doi: 10.3390/molecules181215126.

Polyketides from the halotolerant fungus Myrothecium sp. GS-17.

Author information

  • 1Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang 110001, China. taoliu0307@163.com.

Abstract

Two new polyketides, myrothecol (1) and 5-hydroxy-3-methyl-4-(1-hydroxylethyl)-furan-2(5H)-one (2), were isolated from the fermentation broth of the halotolerant fungus Myrothecium sp. GS-17 along with three known compounds, 5-hydroxyl-3-[(1S)-1-hydroxyethyl]-4-methylfuran-2(5H)-one (3), 3,5-dimethyl-4- hydroxylmethyl-5-methoxyfuran-2(5H)-one (4), and 3,5-dimethyl-4-hydroxymethyl-5- hydroxyfuran-2(5H)-one (5). Compound 1 is the first natural occurring polyketide with a unique furylisobenzofuran skeleton. The structures of these compounds were established via extensive spectroscopic analyses including 1D-, 2D-NMR, HRESI-MS, and crystal X-ray diffraction analysis.

PMID:
24322495
[PubMed - in process]
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