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Pediatr Res. 2014 Mar;75(3):424-30. doi: 10.1038/pr.2013.235. Epub 2013 Dec 9.

Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy.

Collaborators (166)

Jobe AH, Caplan MS, Oh W, Vohr BR, Stephens BE, Hensman AM, Noel L, Watson VE, Leach T, Fanaroff A, Wilson-Costello DE, Newman NS, Siner BS, Bass N, Friedman HG, Donovan EF, Bridges K, Steichen JJ, Yolton K, Alexander B, Grisby C, Mersmann MW, Mincey HL, Hessling J, Gratton TL, Auten KJ, Fisher KA, Foy KA, Grimes S, Gustafson KE, Lohmeyer MB, Adams-Chapman I, Carlton DP, Jain L, Blackwelder AM, Carter S, Hale EC, Fritz S, LaRossa MM, Wright LL, McClure EM, Archer SW, Lemons JA, Dusick AM, Herron DE, Miller LC, Richard L, Wilson LD, Poole W, Wallace D, Hammond J, Auman JO, Cunningham M, Hastings BK, McClure EM, Newman JE, Huitema CM, Schaefer SE, Zaterka-Baxter KM, Stevenson DK, Hintz SR, Rhine WD, Ball M, DeAnda ME, DeBattista AM, Fleisher BE, Kohn JG, Baran JM, Lee-Ancajas JC, Ambalavanan N, Nelson KG, Peralta-Carcelen M, Collins MV, Cosby SS, Phillips VA, Smith LL, Vaucher YE, Kaegi D, Rasmussen MR, Kaegi D, Arnell K, Demetrio C, Fuller MG, Henderson C, Rich W, West R, Bauer CR, Everett-Thomas R, Hiriart-Fajardo S, Allison M, Calejo M, Eguaras SM, Worth AM, Diaz AN, Gideon YC, Jean-Gilles L, Garcia A, Pierre H, Stoerger A, Berkowits MH, Hamlin-Smith K, Phelps DL, Myers GJ, Reubens LJ, Hust D, Johnson JB, Jensen RL, Kushner E, Merzbach J, Yost K, Zwetsch L, Laptook AR, Sánchez PJ, Rosenfeld CR, Broyles R, Heyne RJ, Adams SS, Boatman C, Dooley C, Guzman A, Hensley G, Heyne E, Hickman JF, Madden LA, Madison S, Miller NA, Morgan JS, Torres LE, Tyson JE, Bradt PJ, Evans PW, Major-Kincade T, Morris BH, Akpa EG, Alaniz NI, Cedillo M, Cluff PA, Dieterich S, Franco CI, Jiminez M, Lis AE, McDavid GE, Tate PL, Poundstone M, Reddoch S, Siddiki S, Simmons MC, Valdés LM, Whitely LL, Wright SL, O'Shea T, Dillard RG, Washburn LK, Jackson BG, Peters N, Pappas A, Johnson YR, Bara R, Muran G, Kennedy D, Gettner P, Konstantino M, Poulsen J, Romano E, Williams J, DeLan S.

Author information

  • 1Department of Pediatrics, Duke University, Durham, North Carolina.
  • 2Social, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, North Carolina.
  • 3Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
  • 4Division of Neonatology, University of Alabama at Birmingham, Birmingham, Alabama.
  • 5Department of Pediatrics, University of Texas Medical School at Houston, Houston, Texas.
  • 6Division of Neonatology, University of California, San Diego, San Diego, California.
  • 7Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve, Cleveland, Ohio.
  • 8Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
  • 9Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, Rhode Island.
  • 10University of Rochester School of Medicine and Dentistry, Rochester, New York.
  • 11Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • 12Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
  • 13Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
  • 14Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.
  • 15Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • 16University of Miami Miller School of Medicine, Miami, Florida.
  • 17Social, Statistical, and Environmental Sciences, RTI International, Rockville, Maryland.
  • 18Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
  • 19Department of Pediatrics, Wayne State University, Detroit, Michigan.

Abstract

BACKGROUND:

Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart disease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after hypoxic-ischemic encephalopathy (HIE).

METHODS:

We conducted a cohort study of infants who survived HIE and had 18-22 mo standardized neurodevelopmental evaluations to assess associations between disability and the APOE genotypes e3/e3, e4/-, and e2/-.

RESULTS:

A total of 139 survivors were genotyped. Of these, 86 (62%) were of the e3/e3, 41 (29%) were of the e4/-, and 14 (10%) were of the e2/- genotypes. One hundred and twenty-nine infants had genotype and follow-up data; 26% had moderate or severe disabilities. Disability prevalence was 30 and 19% among those with and without the e3/e3 genotype, 25 and 26% among those with and without the e2 allele, and 18 and 29% among those with and without the e4 allele, respectively. None of the differences were statistically significant. CP prevalence was also similar among genotype groups.

CONCLUSION:

Disability was not associated with the APOE genotype in this cohort of HIE survivors.

PMID:
24322171
[PubMed - in process]
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