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Cell Immunol. 2013 Nov-Dec;286(1-2):45-52. doi: 10.1016/j.cellimm.2013.11.003. Epub 2013 Nov 20.

Crohn's disease: a review of treatment options and current research.

Author information

  • 1Georgia Regents University, Medical College of Georgia, Augusta, GA, United States. Electronic address: sbandzar@gru.edu.
  • 2Emory University School of Medicine, Atlanta, GA, United States.
  • 3Georgia Institute of Technology, Coulter Department of Biomedical Engineering, Atlanta, GA, United States.

Abstract

Crohn's disease is an autoimmune disorder that affects nearly 1.4 million Americans. The etiology of Crohn's disease is not completely understood, however, research has suggested a genetic link. There is currently no known cure for Crohn's disease and, as a result, most government-funded research is being conducted to increase the quality of life of afflicted patients (i.e. reducing chronic inflammation and alleviating growth impairment in pediatric patients). A number of treatment options are available including an alpha-4 integrin inhibitor and several TNF-alpha inhibitors. Furthermore, research is being conducted on several alternative treatment options to help understand exactly which cellular mechanisms (i.e. inducing apoptosis in leukocytes) are required for clinical efficacy. This review seeks to chronicle the current available treatment options for patients affected by Crohn's disease to aid in understanding potential cellular mechanistic requirements for an efficacious drug, and shed light on potential options for future treatment.

Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Crohn’s disease; DC; IL; TNF; TNF-alpha blocker; dendritic cell; interleukin; tumor necrosis factor

PMID:
24321565
[PubMed - indexed for MEDLINE]
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