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Biomed Res Int. 2013;2013:848265. doi: 10.1155/2013/848265. Epub 2013 Nov 11.

Changes in Otx2 and parvalbumin immunoreactivity in the superior colliculus in the platelet-derived growth factor receptor-β knockout mice.

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  • 1System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan ; Department of Anatomy, Histology and Embryology, Shanghai Medical School, Fudan University, Shanghai 200032, China.

Abstract

The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and β subunit of receptors of platelet-derived growth factor (PDGFR- β ) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR- β -knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR- β KO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR- β KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR- β KO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR- β KO mice. These findings suggest that PDGFR- β plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.

PMID:
24319691
[PubMed - indexed for MEDLINE]
PMCID:
PMC3844215
Free PMC Article
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