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Cell Stem Cell. 2013 Dec 5;13(6):635-6. doi: 10.1016/j.stem.2013.11.017.

Inducing cellular aging: enabling neurodegeneration-in-a-dish.

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  • 1Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address:


The immaturity of neurons differentiated from human induced pluripotent stem cells (hiPSCs) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease. Now, Miller et al. (2013) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons, enabling in vitro study of late-onset neurodegenerative diseases.

Copyright © 2013 Elsevier Inc. All rights reserved.

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