Parkinson's disease: less epileptic seizures, more status epilepticus

Berend Feddersen; Jan Rémi; Marion Einhellig; Cordula Stoyke; Philipp Krauss; Soheyl Noachtar

doi:10.1016/j.eplepsyres.2013.11.013

Parkinson's disease: less epileptic seizures, more status epilepticus

Epilepsy Res. 2014 Feb;108(2):349-54. doi: 10.1016/j.eplepsyres.2013.11.013. Epub 2013 Nov 21.

Authors

Berend Feddersen¹, Jan Rémi², Marion Einhellig², Cordula Stoyke², Philipp Krauss², Soheyl Noachtar²

Affiliations

¹ Epilepsy Center, Department of Neurology, University of Munich, Germany. Electronic address: berend.feddersen@med.uni-muenchen.de.
² Epilepsy Center, Department of Neurology, University of Munich, Germany.

PMID: 24315021
DOI: 10.1016/j.eplepsyres.2013.11.013

Abstract

We compared the rate of epilepsy and status epilepticus (SE) in patients with and without Parkinson's disease (PD). Out of 1215 patients with idiopathic PD, 31 had epilepsy and 19 of these had at least one episode of SE (61.3%) compared to 298 of 2537 patients (11.7%; p<0.001) with epilepsy and without concomitant PD. This clinical finding supports the hypothesis that the functional impairment of the basal ganglia in PD patients makes SE more likely.

Keywords: Dopamine; Epilepsy; Parkinson's disease; Seizure; Status epilepticus.

Publication types

Comparative Study

MeSH terms

Aged
Aged, 80 and over
Epilepsy / diagnosis*
Epilepsy / epidemiology*
Female
Humans
Male
Middle Aged
Parkinson Disease / diagnosis*
Parkinson Disease / epidemiology*
Retrospective Studies
Status Epilepticus / diagnosis*
Status Epilepticus / epidemiology*