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Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1160-2. doi: 10.1002/anie.201309073. Epub 2013 Dec 5.

Short and sweet: (D)-glucose to (L)-glucose and (L)-glucuronic acid.

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  • 1Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA (UK).


The scarcity and expense of access to L-sugars and other rare sugars have prevented the exploitation of their biological potential; for example D-psicose, only recently available, has been recognized as an important new food. Here we give the definitive and cheap synthesis of 99.4% pure L-glucose from D-glucose which requires purification of neither intermediates nor final product other than extraction into and removal of solvents; a simple crystallization will raise the purity to >99.8%.

Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


L-glucose; carbohydrates; organic synthesis; rare sugars

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