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J Histochem Cytochem. 2014 Mar;62(3):172-84. doi: 10.1369/0022155413517701. Epub 2013 Dec 5.

Protein kinase C, focal adhesions and the regulation of cell migration.

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  • 1Department of Biomedical Sciences, University of Copenhagen, Denmark.

Abstract

Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.

KEYWORDS:

Adhesion; Cytoskeleton; Kinase; Microfilaments; Proteoglycan

PMID:
24309511
[PubMed - indexed for MEDLINE]
PMCID:
PMC3935447
[Available on 2015/3/1]
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