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Gene. 2014 Feb 10;535(2):218-24. doi: 10.1016/j.gene.2013.11.031. Epub 2013 Dec 3.

Increased expression of mdig predicts poorer survival of the breast cancer patients.

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  • 1Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA.
  • 2Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA; Institute of Respiratory Diseases, First Affiliated Hospital, China Medical University, Shenyang, China; Respiratory Medicine, The 4th Affiliated Hospital, China Medical University, Liaoning Province, China.
  • 3Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA; Institute of Respiratory Diseases, First Affiliated Hospital, China Medical University, Shenyang, China; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning Province, China.
  • 4Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA. Electronic address: fchen@wayne.edu.

Abstract

Breast cancer is the most common cancer and the second leading cause of cancer death among women of all races and Hispanic origin populations in the United States. In the present study, we reported that the survival time of the breast cancer patients is influenced by the expression level of mdig, a previously identified lung cancer-associated oncogene encoding a JmjC-domain protein. By checking the expression levels of mRNA and protein of mdig through both RT-PCR and immunohistochemistry in samples from 204 patients, we noticed that about 30% of breast cancer samples showed increased expression of mdig. Correlation of the mdig expression levels with the survival time of the breast cancer patients indicated a clear inverse relationship between mdig expression and patient survival, including poorer overall survival, distant metastasis free survival, relapse free survival, and post-progression survival. Taken together, these data suggest that an increased expression of mdig is an important prognostic factor for poorer survival time of the breast cancer patients.

Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

ACC; BRCA1; Breast cancer; DCIS; DMFS; HRT; IDC; ILC; Mdig; OS; PPS; Patient survival; Prognosis; RFS; adenoid cystic carcinoma; breast cancer 1 gene; distant metastasis free survival; ductal carcinoma in situ; hormone replacement therapy; invasive ductal carcinoma; invasive lobular carcinoma; mineral dust-induced gene; overall survival; post-progression survival; relapse free survival

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