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Lung Cancer. 2014 Feb;83(2):272-8. doi: 10.1016/j.lungcan.2013.11.005. Epub 2013 Nov 14.

Positive prognostic impact of miR-210 in non-small cell lung cancer.

Author information

  • 1Department of Clinical Medicine, University of Tromso, Norway. Electronic address: marte.eilertsen@uit.no.
  • 2Department of Clinical Medicine, University of Tromso, Norway; Department of Oncology, University Hospital of North Norway, Tromso, Norway.
  • 3Department of Medical Biology, University of Tromso, Norway; Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway.
  • 4Department of Clinical Medicine, University of Tromso, Norway.
  • 5Department of Medical Biology, University of Tromso, Norway; Department of Pathology, Nordland Central Hospital, Bodo, Norway.

Abstract

OBJECTIVES:

miR-210 is an important regulator of the cellular response to hypoxia. Therefore, we aimed to explore the prognostic significance of miR-210 in non-small cell lung cancer (NSCLC) patients with stage I-IIIA disease.

MATERIALS AND METHODS:

In addition to clinicopathological and demograpic information, tumor tissues were collected and tissue micro arrays (TMAs) were constructed from 335 patients with stage I-IIIA NSCLC. Expression of miR-210 in cancer cells and stromal cells of the tumor was assessed by in situ hybridization.

RESULTS:

In univariate analyses, high cancer cell (p=0.039) and high stromal cell expression (p=0.008) of miR-210 were both significantly associated with an improved disease-spesific survival (DSS). High co-expression of miR-210 in cancer and stromal cells was also a positive prognostic factor for DSS (p=0.010). In multivariate analysis, miR-210 in stromal cells (p=0.011), and miR-210 co-expressed in cancer and stromal cells was an independent prognosticator for DSS (p=0.011).

CONCLUSIONS:

We show that miR-210 in stromal cells, and co-expressed in cancer cells and stromal cells mediates an independent prognostic impact. It is a candidate marker for prognostic stratification in NSCLC.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Biomarker; Cancer cells; NSCLC; Prognosis; Tumor stromal cells; miR-210

PMID:
24305009
[PubMed - indexed for MEDLINE]
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