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Int J Gynecol Pathol. 2014 Jan;33(1):58-63. doi: 10.1097/PGP.0b013e31827cd386.

Genotyping diagnosis of nongestational choriocarcinoma involving fallopian tube and broad ligament: a case study.

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  • 1Departments of Pathology (N.B., P.H.) Obstetrics, Gynecology and Reproductive Sciences (T.R., P.H.), Yale University School of Medicine, New Haven, Connecticut.


A 22 year-old G1P1 woman presented to the emergency room with clinical impression of "ruptured right adnexal mass" and underwent a right salpingo-oophorectomy to rule out ectopic pregnancy. Instead, gross and microscopic examination revealed a pure choriocarcinoma involving the right fallopian tube and broad ligament. On the basis of the patient's age, recent history of delivery, last menstrual period for 10 weeks, large tumor mass, and possible pelvic lymph node metastasis, the patient promptly started to receive 8 cycles of multiagent chemotherapy regimen with a working diagnosis of high-risk gestational choriocarcinoma. Subsequent DNA genotyping analysis showed that the tumor cells had an identical genetic profile to that of the normal tissue of the patient, therefore establishing a final diagnosis of nongestational choriocarcinoma. Six months after the initial presentation, a second surgery was performed to remove a persistent right para-adnexal mass, which showed only necrotic tissue upon microscopic examination. The patient received 1 additional cycle of multiagent chemotherapy. She was alive without evidence of recurrence 26 months after the initial diagnosis.

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