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Evolution. 2013 Dec;67(12):3512-22. doi: 10.1111/evo.12207. Epub 2013 Aug 2.

Shifting fitness landscapes in response to altered environments.

Author information

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605.

Abstract

The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade-offs between mutations in different environments.

© 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.

KEYWORDS:

Adaptation; Fisher's geometric model; adaptive walk; distribution of fitness effects; experimental evolution

PMID:
24299404
[PubMed - indexed for MEDLINE]
PMCID:
PMC3855258
Free PMC Article
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