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Nat Cell Biol. 2013 Dec;15(12):1403-4. doi: 10.1038/ncb2890.

Redox switch for actin.

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  • 1Heinrich-Heine-Universität Düsseldorf, AG Funktionelle Zellmorphologie, Universitätsstraße 1, Geb. 26-12-00, 40223 Düsseldorf, Germany.


Oxidation of actin methionine residues by the oxidation-reduction enzyme Mical is known to lead to actin filament depolymerization. SelR enzymes are now shown to reduce these oxidized actin methionines, revealing a regulated redox reaction mechanism through which cells control the assembly and disassembly of actin filaments.

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