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Vaccine. 2014 Feb 12;32(8):909-17. doi: 10.1016/j.vaccine.2013.11.068. Epub 2013 Dec 2.

Development of immunization trials against Pasteurella multocida.

Author information

  • 1Scientific Support and Projects Section, Bibliotheca Alexandrina, Alexandria, Egypt. Electronic address:
  • 2Biotechnology Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.
  • 3Immunology Department, Medical Researches Institute, Alexandria University, Alexandria, Egypt.


Pasteurellosis is one of the most important respiratory diseases facing economically valuable farm animals such as poultry, rabbit, cattle, goats and pigs. It causes severe economic loss due to its symptoms that range from primary local infection to fatal septicemia. Pasteurella multocida is the responsible pathogen for this contagious disease. Chemotherapeutic treatment of Pasteurella is expensive, lengthy, and ineffective due to the increasing antibiotics resistance of the bacterium, as well as its toxicity to human consumers. Though, biosecurity measures played a role in diminishing the spread of the pathogen, the immunization methods were always the most potent preventive measures. Since the early 1950s, several trials for constructing and formulating effective vaccines were followed. This up-to-date review classifies and documents such trials. A section is devoted to discussing each group benefits and defects.

Copyright © 2013 Elsevier Ltd. All rights reserved.


Immunotherapy; Pasteurella multocida; Pasteurellosis; Vaccine

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