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Clin Transl Allergy. 2013 Dec 2;3(1):40. doi: 10.1186/2045-7022-3-40.

Plasma IL-25 is elevated in a subgroup of patients with clinical reactivity to peanut.

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  • 1Laboratory for Translational Immunology, Department of Paediatric Immunology, University Medical Centre, PO BOX 85090, Utrecht 3508 AB, The Netherlands. F.vanwijk@umcutrecht.nl.



One of the IL-17 family members, IL-25, has been implicated with the initiation and amplification of Th2 responses in animal models and has been associated with airway hyper-reactivity. The involvement of IL-25 and also IL-17 in food allergic disease remains to be investigated.


In this study thirty children suspected of peanut allergic disease underwent a double-blind placebo controlled food challenge (DBPCFC) and IL-25 and IL-17 plasma levels were determined before and after challenge. IL-25 was highly elevated only in subgroup of children with a positive DBPCFC outcome. Plasma IL-25 was absent in children with a negative DBPCFC outcome and in healthy controls.


This study shows that IL-25, an IL-17 family member, is highly elevated only in children with a clinical response to peanut. This suggests a role for IL-25 in the pathogenesis of peanut allergy and elevated plasma IL-25 may be a sign of a severe atopic phenotype.

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