Abstract
Twelve new dibenzoyl derivatives sophodibenzoside A-L (1-12) and five new isoflavone glycosides (13-17) have been isolated from the roots of Sophora flavescens together with eight known compounds (18-25). Notably, the use of acetic acid-d4 was required to enable identification of the dibenzoyl glycoside structures. Compounds 1, 2, 13, 14, and 19 exhibited weak inhibition of the cytotoxic effect of d-galactosamine on the human hepatic cell line HL-7702.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid / pharmacology
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Benzoates / chemistry
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Benzoates / isolation & purification*
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Benzoates / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Galactosamine / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Hepatocytes / drug effects*
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Humans
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Molecular Structure
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Nitric Oxide Synthase Type II
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Plant Roots / chemistry
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Sophora / chemistry*
Substances
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Benzoates
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Drugs, Chinese Herbal
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Flavonoids
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Glycosides
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Galactosamine
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NOS2 protein, human
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Nitric Oxide Synthase Type II
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Acetic Acid