Format

Send to:

Choose Destination
See comment in PubMed Commons below
Radiol Oncol. 2013 Oct 8;47(4):319-29. doi: 10.2478/raon-2013-0053. eCollection 2013.

Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies.

Author information

  • 1Clinical Research Unit, Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technische Universit√§t M√ľnchen, Munich, Germany.

Abstract

BACKGROUND:

Tumor tissue-associated KLKs (kallikrein-related peptidases) are clinically important biomarkers that may allow prognosis of the cancer disease and/or prediction of response/failure of cancer patients to cancer-directed drugs. Regarding the female/male reproductive tract, remarkably, all of the fifteen KLKs are expressed in the normal prostate, breast, cervix uteri, and the testis, whereas the uterus/endometrium and the ovary are expressing a limited number of KLKs only.

CONCLUSIONS:

Most of the information regarding elevated expression of KLKs in tumor-affected organs is available for ovarian cancer; depicting them as valuable biomarkers in the cancerous phenotype. In contrast, for breast cancer, a series of KLKs was found to be downregulated. However, in breast cancer, KLK4 is elevated which is also true for ovarian and prostate cancer. In such cases, selective synthetic KLK inhibitors that aim at blocking the proteolytic activities of certain KLKs may serve as future candidate therapeutic drugs to interfere with tumor progression and metastasis.

KEYWORDS:

breast; cancer, proteases; cervix; endometrium; ovary; prostate; testis; uterus

PMID:
24294176
[PubMed]
PMCID:
PMC3814276
Free PMC Article

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk