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Clin Calcium. 2013 Dec;23(12):1789-94. doi: CliCa131217891794.

[Clinical condition and therapy of bone diseases].

[Article in Japanese]

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  • 1Department of pediatrics, Osaka Graduate School of Medicine, Japan.

Abstract

Skeletal dysplasia is the term which represents disorders including growth and differentiation of bone, cartilage and ligament. A lot of diseases are included, and new disorders have been added. However, the therapy of most bone diseases is less well-established. Achondroplasia, hypochondroplasia, and osteogenesis imperfecta are most frequent bone diseases. There is no curative treatment for these diseases, however, supportive therapies are available ; for example, growth-hormone therapy for achondroplasia and hypochondroplasia, and bisphosphonate therapy for osteogenesis imperfecta. In addition, enzyme replacement therapy for hypophosphatasia is now on clinical trial.

[PubMed - indexed for MEDLINE]
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