Format

Send to

Choose Destination
See comment in PubMed Commons below
Phytomedicine. 2014 Mar 15;21(4):529-33. doi: 10.1016/j.phymed.2013.10.004. Epub 2013 Nov 27.

Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of airway mucin in vitro.

Author information

  • 1Department of Pharmacology, School of Medicine, Chungnam National University, Daejeon 303-131, Republic of Korea.
  • 2Department of Pharmacy, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
  • 3Division of Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
  • 4Department of Pharmacology, School of Medicine, Chungnam National University, Daejeon 303-131, Republic of Korea. Electronic address: LCJ123@cnu.ac.kr.

Abstract

We investigated whether aqueous extract of the root of Platycodon grandiflorum A. de Candolle (APG), platycodinD(3) and deapi-platycodin significantly affect the production and secretion of airway mucin using in vivo and in vitro experimental models. Effect of APG was checked on hypersecretion of pulmonary mucin in sulfur dioxide-induced bronchitis in rats. Confluent NCI-H292 cells were pretreated with platycodinD(3) or deapi-platycodin for 30min and then stimulated with PMA (phorbol 12-myristate 13-acetate) for 24h. The MUC5AC mucin production and secretion were measured by ELISA. The results were as follows: (1) APG stimulated the secretion of airway mucin in sulfur dioxide-induced bronchitis rat model; (2) platycodinD(3) and deapi-platycodin inhibited the production of MUC5AC mucin induced by PMA from NCI-H292 cells, respectively; (3) however, platycodinD(3) and deapi-platycodin did not inhibit but stimulated the secretion of MUC5AC mucin induced by PMA from NCI-H292 cells, respectively. This result suggests that aqueous extract of P. grandiflorum A. de Candolle and the two natural products derived from it, platycodinD(3) and deapi-platycodin, can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extract of P. grandiflorum A. de Candolle as expectorants in diverse inflammatory pulmonary diseases.

Copyright © 2013 Elsevier GmbH. All rights reserved.

KEYWORDS:

Airway mucin; Deapi-platycodin; PlatycodinD(3)

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk