Format

Send to:

Choose Destination
See comment in PubMed Commons below
FEBS J. 2014 Mar;281(5):1355-65. doi: 10.1111/febs.12659. Epub 2014 Feb 10.

MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6.

Author information

  • 1Eye Hospital, First Affiliated Hospital, Harbin Medical University, China.

Abstract

Our study demonstrates the downregulation of microRNA-183 (miR-183) in retinoblastoma (RB) tissues and RB cell lines compared with normal retinal tissues. The ectopic expression of miR-183 in the RB cell lines Y79, SO-RB50 and WERI-RB1 suppresses cell viability, migration and invasion. Furthermore, the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) was identified as a new target of miR-183, and restoration of the expression of LRP6 rescues the effects induced by miR-183 in RB cells. These results indicate that miR-183 targets and downregulates LRP6 in the growth, migration and invasion of RB cells.

© 2013 FEBS.

KEYWORDS:

LRP6; cell growth; cell invasion; microRNA-183; retinoblastoma

PMID:
24289859
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk