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FEBS J. 2014 Mar;281(5):1355-65. doi: 10.1111/febs.12659. Epub 2014 Feb 10.

MicroRNA-183 suppresses retinoblastoma cell growth, invasion and migration by targeting LRP6.

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  • 1Eye Hospital, First Affiliated Hospital, Harbin Medical University, China.


Our study demonstrates the downregulation of microRNA-183 (miR-183) in retinoblastoma (RB) tissues and RB cell lines compared with normal retinal tissues. The ectopic expression of miR-183 in the RB cell lines Y79, SO-RB50 and WERI-RB1 suppresses cell viability, migration and invasion. Furthermore, the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) was identified as a new target of miR-183, and restoration of the expression of LRP6 rescues the effects induced by miR-183 in RB cells. These results indicate that miR-183 targets and downregulates LRP6 in the growth, migration and invasion of RB cells.

© 2013 FEBS.


LRP6; cell growth; cell invasion; microRNA-183; retinoblastoma

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