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Bull Exp Biol Med. 2013 Sep;155(5):628-30.

Analysis of biochemical changes in rat erythrocytes induced by long-term simvastatin treatment.

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  • 1Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health Care of the Russian Federation, Russia.


Analysis of metabolic changes in rat erythrocytes against the background of long-term simvastatin treatment revealed an increase in glycolysis metabolite concentrations and glucose-6-phosphate dehydrogenase activity and oppositely directed shifts in antioxidant defense enzyme activities. It was demonstrated that hypoxia and imbalance in the antioxidant enzyme system contribute to the development of side effects of statins.

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