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BMB Rep. 2013 Nov 21. pii: 2370. [Epub ahead of print]

WITHDRAWN: Selenite induces apoptosis in colorectal cancer cells through interaction with thioredoxin reductase.

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  • 1The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China caiminxu@yahoo.com.cn.

Abstract

Ahead of Print article withdrawn by publisher. The chemopreventive and chemotherapeutic effects of selenium compounds has been well validated in colorectal cancer by epidemiologic and pre-clinical studies, but the underlying mechanisms still remains elusive. We provide evidence that interaction between selenium metabolites and selenoproteins participates in colorectal cancer suppression induced by selenite. We found that supranutritional doses of selenite could induces inhibition of thioredoxin system and apoptosis in SW480 cells, and cause direct modifications of thiol groups on TrxR protein. Moreover, we showed that TrxR ablation sensitized apoptosis induced by selenite, and the synergistic effect was related to Bax activation and mitochondrial apoptotic pathway. Our results proposed that TrxR is an important target for selenite in colorectal cancer suppression, and selenite in combination with TrxR inhibition could be an effective strategy to treat colorectal cancer.

PMID:
24286309
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