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J Med Imaging Radiat Oncol. 2013 Dec;57(6):674-9. doi: 10.1111/1754-9485.12077. Epub 2013 Jun 24.

18 FDG PET and PET-CT for the detection of bone metastases in patients with head and neck cancer. A meta-analysis.

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  • 1Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China.

Abstract

INTRODUCTION:

We performed a meta-analysis to evaluate (18) FDG PET/PET-CT for the detection of bone metastases in patients with head and neck cancer.

METHODS:

We calculated sensitivities, specificities, likelihood ratios, and constructed summary receiver operating characteristic curves for PET and PET-CT, respectively. We also compared the performance of PET/PET-CT with that of bone scintigraphy by analysing studies that had also used bone scintigraphy on the same patients.

RESULTS:

Across 9 PET studies (1621 patients) and 10 PET-CT studies (1291 patients), sensitivity and specificity of PET were 0.81 and 0.99, and of PET-CT were 0.89 and 0.99, respectively. In 5 comparative studies (1184 patients), sensitivity and specificity of PET/PET-CT were 0.85 and 0.98, and of bone scintigraphy were 0.55 and 0.98, respectively.

CONCLUSIONS:

(18) FDG PET and PET-CT have high sensitivity and accuracy for the detection of bone metastasis in patients with head and neck cancer.

© 2013 The Authors. Journal of Medical Imaging and Radiation Oncology © 2013 The Royal Australian and New Zealand College of Radiologists.

KEYWORDS:

18FDG PET; bone metastases; head and neck neoplasms; meta-analysis

PMID:
24283555
[PubMed - indexed for MEDLINE]
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