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Expert Opin Ther Targets. 2014 Feb;18(2):153-8. doi: 10.1517/14728222.2014.855201. Epub 2013 Nov 27.

MicroRNA-323-3p with clinical potential in rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy.

Author information

  • 1Anhui Medical University, School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products , Anhui Province, 81 Meishan Road, Hefei 230032 , China +86 551 65161001 ; +86 551 65161001 ; lj@ahmu.edu.cn , ahmuxutao@163.com.

Abstract

INTRODUCTION:

MicroRNAs (miRNAs) are a group of noncoding RNAs,∼ 20 - 22 nucleotides in length, that repress target gene expression through mRNA degradation and translation inhibition. The gene encoding miR-323-3p, which is a biomarker in immune and inflammatory responses, exists in a miRNA cluster in chromosomal region 14q32.31. It has been shown that miR-323-3p associates with the pathogenesis of several diseases, such as rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy.

AREAS COVERED:

This review provides a current view on the association of miR-323-3p with several human diseases and is focused on the recent studies of miR-323-3p regulation, discussing its potential as an epigenetic biomarker and therapeutic target for these diseases. In particular, the mechanisms of miR-323-3p in these diseases and how miR-323-3p is regulated are also discussed.

EXPERT OPINION:

Although the exact role of miR-323-3p in these diseases has not been fully elucidated, targeting miR-323-3p may serve as a promising therapy strategy.

PMID:
24283221
[PubMed - indexed for MEDLINE]
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