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Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13067-70. doi: 10.1002/anie.201305382. Epub 2013 Nov 7.

Elucidating the neurotoxicity of the star fruit.

Author information

  • 1Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP (Brazil). ngcairas@fmrp.usp.br.

Abstract

Caramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

natural products; neurological agents; neurotoxins; receptors; star fruit

PMID:
24281890
[PubMed - indexed for MEDLINE]
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