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Gastroenterol Clin North Am. 2013 Dec;42(4):893-912. doi: 10.1016/j.gtc.2013.09.005.

Anal squamous intraepithelial neoplasia.

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  • 1RT Institute of Pathology and Laboratory Medicine, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA.


Diagnosis, follow up, and treatment of anal intraepithelial neoplasia are complex and not standardized. This may be partly caused by poor communication of biopsy and cytology findings between pathologists and clinicians as a result of a disparate and confusing terminology used to classify these lesions. This article focuses on general aspects of epidemiology and on clarifying the current terminology of intraepithelial squamous neoplasia, its relationship with human papilloma virus infection, and the current methods that exist to diagnose and treat this condition.

Copyright © 2013 Elsevier Inc. All rights reserved.


Anal carcinoma; Anal intraepithelial neoplasia; Dysplasia; Human papilloma virus

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