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Nature. 1986 Sep 4-10;323(6083):36-9.

Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel.


Osmotic stress can be used to estimate the internal volume change during the opening and closing of a voltage gated ionic channel. Mitochondrial voltage-dependent anion channels, from rat liver and from Neurospora, reconstituted into planar lipid bilayers show a change of 2 to 4 X 10(4) A3 in internal volume, a large change inconsistent with a blocking or local gating model but supporting models with major closure of the channel space.

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