Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Liver Dis. 2014 Feb;18(1):165-78. doi: 10.1016/j.cld.2013.09.015.

The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease.

Author information

  • 1Department of Hepatogastroenterology, Université Pierre et Marie Curie, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Inserm UMR_S 938, Paris 75013, France.

Abstract

Steatosis and insulin resistance (IR) are no more frequent in chronic hepatitis B (CHB) than in the general population. Although experimental studies suggest that the HBx protein induces liver fat, human studies have shown that steatosis and IR are related to coexistent metabolic risk factors, thus epidemiologically linked rather than virally induced. Diabetes and obesity are associated with advanced fibrosis and increased risk of hepatocellular carcinoma in CHB. Despite abundant experimental data showing that fatty liver is more susceptible to liver injury, drug-induced liver disease seems no more frequent in NAFLD patients, except, possibly, a higher incidence but not severity of acetaminophen hepatotoxicity.

Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Chronic hepatitis B; Cirrhosis; Drug-induced liver injury; Fatty liver; Fibrosis; Hepatocellular carcinoma; Metabolic syndrome; Steatosis

PMID:
24274872
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk