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Clin Liver Dis. 2014 Feb;18(1):19-31. doi: 10.1016/j.cld.2013.09.018. Epub 2013 Oct 24.

Obesity-associated nonalcoholic fatty liver disease.

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  • 1Department of Gastroenterology, School of Medicine, Marmara University, Fevzi Cakmak Mah, Mimar Sinan Cad. No. 41 Ust Kaynarca, Pendik, Istanbul 34899, Turkey; Institute of Gastroenterology, Marmara University, Karaciger Arastirmalari Birimi, Basibuyuk, Maltepe, Istanbul 34840, Turkey.


Obesity is strongly associated with the prevalence of nonalcoholic fatty liver disease (NAFLD) in adult and pediatric populations. Nutrition, physical activity, and behavioral modifications are critical components of the treatment regimen for all obese patients with NAFLD. Bariatric surgeries that affect or restrict the flow of food through the gastrointestinal tract may improve liver histology in morbidly obese patients with nonalcoholic steatohepatitis (NASH), although randomized clinical trials and quasi-randomized clinical studies are lacking. Early detection of NASH and hepatic fibrosis using noninvasive biochemical and imaging markers that may replace liver biopsy is the current challenge.

Copyright © 2014 Elsevier Inc. All rights reserved.


Epidemiology; Nonalcoholic fatty liver disease; Obesity; Pathophysiology

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