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Nat Genet. 2013 Dec;45(12):1412-3. doi: 10.1038/ng.2834.

Epigenetics, vitamin supplements and cellular reprogramming.

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  • 1Department of Anatomy and Neuroscience, University of Melbourne, the Walter and Eliza Hall Institute of Medical Research, and the Florey Neuroscience and Mental Health Institute, Melbourne, Victoria, Australia.


The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or enhance reprogramming efficiency, dependent on the presence or absence of vitamin C.

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