Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Exp Hematol. 2014 Feb;42(2):74-82.e2. doi: 10.1016/j.exphem.2013.11.004. Epub 2013 Nov 20.

Heterogeneity and hierarchy of hematopoietic stem cells.

Author information

  • 1Department of Cell Differentiation, Sakaguchi Laboratories of Developmental Biology, Keio University School of Medicine, Tokyo, Japan. Electronic address: hema@a7.keio.jp.
  • 2Leibniz Institute for Age Research, Fritz Lipmann Institute, Jenna, Germany.
  • 3Department of Cell Differentiation, Sakaguchi Laboratories of Developmental Biology, Keio University School of Medicine, Tokyo, Japan.

Abstract

Hematopoietic stem cells (HSCs) are a more heterogeneous population than previously thought. Extensive analysis of reconstitution kinetics after transplantation allows a new classifications of HSCs based on lineage balance. Previously unrecognized classes of HSCs, such as myeloid- and lymphoid-biased HSCs, have emerged. However, varying nomenclature has been used to describe these cells, promoting confusion in the field. To establish a common nomenclature, we propose a reclassification of short-, intermediate-, and long-term (ST, IT, and LT) HSCs defined as: ST < 6 months, IT > 6 months, and LT > 12. We observe that myeloid-biased HSCs or α cells overlap with LT-HSCs, whereas lymphoid-biased HSCs or γ/δ cells overlap with ST-HSCs, suggesting that HSC lifespan is linked to cell differentiation. We also suggest that HSC heterogeneity prompts reconsideration of long-term (>4 months) multilineage reconstitution as the gold standard for HSC detection. In this review, we discuss relationships among ST-, IT-, and LT-HSCs relevant to stem cell heterogeneity, hierarchical organization, and differentiation pathways.

Copyright © 2014 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

PMID:
24269919
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk