Send to:

Choose Destination
See comment in PubMed Commons below
Hemodial Int. 2014 Apr;18(2):531-5. doi: 10.1111/hdi.12115. Epub 2013 Nov 25.

Role of sodium thiosulfate therapy in the treatment of digital necrosis due to Mönckeberg sclerosis.

Author information

  • 1Morton Plant Hospital, University of South Florida College of Medicine, Clearwater, Florida, USA; Renal Hypertension Center, Hudson, Florida, USA.


Accelerated vascular calcification is a well-described complication of chronic kidney disease often affecting large and small vessels alike through a variety of mechanisms. Accordingly, dysregulation of calcium and phosphate balance, vitamin D metabolism, hyperparathyroidism, and endothelial injury can lead to both macrovascular and microvascular complications. We describe a 56-year-old Hispanic male with a history of end-stage renal disease, diabetes mellitus type 2, and medical noncompliance who developed sequential digital ischemia and necrosis involving both hands as well as right foot as a result of Mönckeberg sclerosis. An extensive metabolic and serologic workup was unrevealing but radiographic studies and histopathology revealed the diagnosis. A multifaceted approach was instituted including wound debridement and amputations along with intensive medical support. In addition to improving hypertensive control and striving for improved calcium and phosphate balance, sodium thiosulfate solution was administered for more than 1 year. This aggressive approach allowed his wounds to heal and has arrested further digital ischemia from occurring.

© 2013 International Society for Hemodialysis.


Digital necrosis; Mönckeberg Sclerosis; dialysis; gangrene; sodium thiosulfate; vascular calcification

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk